Long-span railway steel truss arch bridges are extremely sensitive to wind loads during cantilever erection, and accurate assessment of their buffeting response critically depends on reliable acquisition of aerodynamic parameters. Traditional wind tunnel tests and three-dimensional (3D) CFD numerical simulations offer high accuracy, but involve long testing cycles and high computational costs, making it difficult to meet rapid analysis requirements for multiple cross-sections and angles of attack during construction. To address this, this paper proposes a rapid identification method for aerodynamic parameters of steel truss segments via two-dimensional (2D) cross-sectional simulations. By applying piecewise weighted averaging to variable cross-section arch ribs along the arch axis, the complex 3D configuration is reduced to a combination of 2D sections, which substantially reduces computational cost while preserving aerodynamic force distribution characteristics. By using wind tunnel test data of a railway steel truss arch bridge with a main span of 400 m as a benchmark, differences between 3D CFD and simplified 2D simulations in predicting tri-component force coefficients are systematically compared. The results show that the 2D-derived coefficients agree well with test data, and buffeting errors are within 6%, indicating that the proposed method significantly improves analytical efficiency while ensuring satisfactory accuracy.

高原低氧致胃肠应激损伤是第三大常见急性高原病，可严重损害急进高原人群的身体健康。目前对高原低氧致胃肠应激损伤的病理机制探索明显不足，相关研究报道较少，防治药物的研发也相对滞后。本文从中医角度出发并结合现代医学，对高原低氧致胃肠应激损伤的病名、病因、病机及基本证型进行论述，总结了具有防治作用的常用中药和复方制剂等，并综述了相关中药的功效特征、活性成分及其作用机制。中药具有多组分、多靶点的作用特性，且资源丰富，在防治高原低氧致胃肠损伤方面兼具传统应用价值与开发潜力。本研究旨在为高原低氧致胃肠应激损伤防治药物研发与临床应用提供参考。

目的 探讨肉桂酸（CA）对糖尿病基因小鼠（db/db）糖代谢及胰岛β细胞功能的影响，并探索其潜在分子机制。方法：首先在高脂饮食诱导的糖尿病模型小鼠（C57BL/6）中进行CA剂量筛选（5、10、20 mg/kg），确定其最佳干预剂量为20 mg/kg。随后以 db/db小鼠为研究对象，随机分为模型组、二甲双胍组及 CA组（20 mg/kg），野生型小鼠为正常组。通过每周监测体重及空腹血糖、进行口服葡萄糖耐量试验（OGTT）及空腹胰岛素检测评价糖代谢及胰岛功能。采用 HE染色、透射电子显微镜及免疫荧光分析评估胰岛形态及β细胞结构。通过转录组学测序、蛋白质互作（PPI）网络分析及 RT-qPCR验证探讨 CA的分子作用机制。结果 与模型组相比，CA组小鼠空腹血糖显著下降（P<0.05），胰岛素抵抗指数（HOMA-IR）显著改善（P<0.01），OGTT显示胰岛对葡萄糖刺激反应增强。HE染色及电子显微镜结果提示 CA改善了胰岛β细胞形态及线粒体结构，免疫荧光分析显示胰岛素含量升高（P<0.05）。转录组学及 RT-qPCR 结果显示 CA显著上调 Ins1/2、Abcc8、Kcnj11、Cacna1c、Camk2b、Snap25、Adcy2等胰岛素分泌相关基因（P<0.05）；京都基因与基因组百科全书（KEGG）富集分析提示其涉及胰岛素分泌通路，PPI网络分析显示 Ins2和 Snap25为核心节点。结论 CA可以通过增强胰岛β细胞功能，促进葡萄糖刺激的胰岛素分泌，改善 db/db 小鼠的糖代谢紊乱。